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. 2018 Nov;367(2):203–214. doi: 10.1124/jpet.118.249904

Fig. 10.

Fig. 10.

The effects of systemic p-CF3 diEPP in the CFA-induced chronic inflammatory pain model. (A) To determine the blockade of the antiallodynic effect of p-CF3 diEPP by the α7 antagonist MLA, MLA was administered systemically (10 mg/kg, s.c.) 15 minutes before p-CF3 diEPP (10 mg/kg, i.p.) injection and mice were tested 30 minutes after administration. *P < 0.05, significantly different from vehicle-vehicle group; #P < 0.05, significantly different from the baseline (BL) group. (B) The anti-inflammatory effect of p-CF3 diEPP (10 mg/kg, i.p.) and its blockade by MLA. The effect was measured by the difference in the ipsilateral paw diameter (ΔPD) before and after CFA injection, and was assessed 1 hour after p-CF3 diEPP and/or MLA injection. *P < 0.05, significantly different from vehicle-vehicle group; Veh, Vehicle.