Fig. 3.

CRC data for the α7 nAChR responses evoked by p-CF₃ diEPP applied alone or coapplied with TQS. (A) The α7 orthosteric activation evoked by p-CF₃ diEPP applied alone at 3, 10, 30, 100, and 300 μM measured as net charge. Each point is the average (±S.E.M.) of at least five cells, normalized to 60 µM ACh control responses from the same cells. (B) The α7 activation evoked by p-CF₃ diEPP (3, 10, 30, 100, and 300 µM) coapplied with 10 µM TQS at −60 mV (red, left-side scale) and at +50 mV (blue, right-side scale). The responses are reported as net charge and normalized to the average net charge value of two control applications of ACh (60 μM) at −60 mV. Each data point represents the average normalized response of at least four cells (±S.E.M.).