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. 2020 Oct 15;11:595902. doi: 10.3389/fmicb.2020.595902

FIGURE 5.

FIGURE 5

Receiver operating characteristic (ROC) curve analysis after multivariable logistic regression for three logit models. Top left, the ROC curve revealed the best predictors to differentiate between NILM and ASCUS/LSIL/HSIL as HPV carcinogenicity, ZNF582_1st CpG site, and ADCY8_5th CpG site. Top right, for differentiating between NILM/ASCUS and LSIL/HSIL cytology, the best multivariate predictor was the combination of HPV carcinogenicity, ZNF582_1st CpG site, CDH8_4th CpG site, and ADCY8_5th CpG site. Bottom, for differentiating between NILM/ASCUS/LSIL and HSIL cytology, the best multivariate predictor was the combination of HPV carcinogenicity, ZNF582_1st CpG site, CDH8_4th CpG site, and ADCY8_6th CpG site. All three multivariable models were better predictors of the specified outcome than HPV carcinogenicity alone (delta AUC*, p < 0.05, chi-square test). AUC, Area under the receiver operator curve (AUC); se, sensitivity; cut-off points (arrows).