Table 2.
Univariable and multivariable analyses of predictors in the study population with and without fatigue (data are presented as the absolute number of patients with percentages in parentheses with the exception of age, which is listed as mean value ± SD)
| Variable† | Fatigue Severity Scale (FSS) | Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|---|---|
| FSS ≥ 4 n = 248 | FSS < 4 n = 108 | Odds ratio (95% CI) | p value | Odds ratio (95% CI) | p value | |
| Age in years at ictus, mean ± SD | 55.4 ± 11.4 | 56.5 ± 14.8 | 0.993 (0.975–1.011) | 0.438 | ||
| Sex, male | 84 (33.9%) | 31 (28.7%) | 1.272 (0.777–2.083) | 0.338 | ||
| Nicotine use at time of ictus | ||||||
| Never | 60 (24.4%) | 46 (43.0%) | 1.000 (ref.) | 0.002 | ||
| Former | 40 (16.3%) | 16 (15.0%) | 1.917 (0.956–3.842) | 0.067 | ||
| Current | 146 (54.1%) | 45 (42.1%) | 2.487 (1.495–4.139) | < 0.001 | 2.104 (1.305–3.394)‡ | 0.002 |
| Aneurysm location | ||||||
| ACoA/ACA | 109 (44.0%) | 39 (36.1%) | 1.000 (ref.) | 0.369 | ||
| MCA/ICA | 102 (41.1%) | 52 (48.1%) | 0.702 (0.428–1.152) | 0.161 | ||
| Vertebrobasilar | 37 (14.9%) | 17 (15.7%) | 0.779 (0.394–1.538) | 0.472 | ||
| Endovascular treatment | 139 (56.3%) | 55 (51.4%) | 1.217 (0.772–1.918) | 0.398 | ||
| Hunt and Hess 4–5 | 57 (23.0%) | 15 (13.9%) | 1.850 (0.995–3.441) | 0.052 | ||
| Glasgow Coma Scale | ||||||
| GCS 15–14 | 151 (60.9%) | 85 (78.7%) | 1.000 (ref.) | 0.006 | 1.000 (ref.) | 0.011 |
| GCS 13–9 | 48 (19.4%) | 11 (10.2%) | 2.456 (1.211–4.981) | 0.013 | 2.490 (1.206–5.140) | 0.014 |
| GCS 8–3 | 49 (19.8%) | 12 (11.1%) | 2.299 (1.159–4.560) | 0.017 | 2.128 (1.034–4.381) | 0.040 |
| Modified Fisher 3–4 | 141 (57.1%) | 45 (41.7%) | 1.862 (1.178–2.944) | 0.008 | 1.403 (0.837–2.350) | 0.198 |
| Modified LeRoux 6–16 | 37 (15.0%) | 17 (15.7%) | 0.943 (0.505–1.762) | 0.854 | ||
| Loss of consciousness at ictus | 114 (46.2%) | 32 (29.6%) | 2.036 (1.256–3.299) | 0.004 | 1.196 (0.630–2.272) | 0.584 |
| Rebleed before treatment | 26 (10.5%) | 4 (3.7%) | 3.045 (1.036–8.950) | 0.043 | 2.680 (0.872–8.236) | 0.085 |
| Severe vasospasm | 50 (20.2%) | 10 (9.3%) | 2.487 (1.210–5.115) | 0.013 | 2.298 (1.095–4.823) | 0.028 |
| Acute hydrocephalus | 179 (72.2%) | 60 (55.6%) | 2.075 (1.297–3.322 | 0.002 | 1.268 (0.712–2.258) | 0.419 |
| Chronic hydrocephalus | 65 (26.2%) | 18 (16.7%) | 1.776 (0.995–3.171) | 0.052 | ||
| Intracerebral hemorrhage | 54 (21.8%) | 18 (16.7%) | 1.392 (0.772–2.508) | 0.271 | ||
| New cerebral infarction | 73 (29.4%) | 24 (22.2%) | 1.460 (0.860–2.479) | 0.161 | ||
†Some variables have missing values (number of missing patients in parentheses): nicotine use at time of ictus (3 missing), treatment modality (2 with spontaneous aneurysm thrombosis are excluded), modified Fisher (1 missing), LeRoux (1 missing), LOCi (1 missing), and severe vasospasm (1 missing). ‡Nicotine use were dichotomized (never/former versus current)