Table 1.
Main CMR features of restrictive cardiomyopathies
| Disease | Wall thickness | Hypertrophy pattern | RV involvement | EDV | EF | LGE (pattern) | nT1 | ECV | T2map | Atrial enlargement |
|---|---|---|---|---|---|---|---|---|---|---|
| Amyloidosis | ↑↑ |
Asymmetrical (ATTR) Symmetrical (AL) |
+ | ↑/~ | ~/↓ | +(diffuse subendocradial/transmural)
|
↑↑ | ↑↑ | ↑/~ | + |
| Fabry disease |
↑↑ (male) ↑ (female) |
Symmetrical | + | ↓/~ | ~/↑ | +(subendocardial inferolateral wall)
|
↓↓ | ↓/~/↑ | ↑/~ | +/− |
| Iron overload | ↑/~ | Symmetrical | + | ↑/~ | ~/↓ | Not frequent (diffuse)
|
↓ | ↓/~/↑ | ↓ | +/− |
| Radiation heart disease | ~ | No | + | ↓/~ | ↓ | + (band-like, not specific)
|
↑ | ↑ | ~ | + |
| Endomyocardial fibrosis | ~ | No | ++ | ↓ | ↓ | +(diffuse subendocardial)
|
~ | ~ | ↑/~ | + |
RV Right ventricle, EDV end-diastolic volume; EF ejection fraction; LGE late gadolinium enhancement, nT1 native T1, ECV extracellular volume, T2map T2 mapping. ↓/~/↑ increase/within normal range/reduced, ± :present/absent