. 2020 Sep 2;107(6):593–602. doi: 10.1007/s00223-020-00751-x

Table 1.

Food intake, BW, doses of T and EN averaged over the weeks and other parameters, measured at the end of the study in Non-Orx and Orx rats treated with enobosarm (EN) or testosterone propionate (T) applied either after Orx (pr, weeks 0–18) or after osteotomy (th, weeks 12–18)

Parameters	Non-Orx		Orx		Orx+T-th		Orx+EN-th		Orx+T-pr		Orx+EN-pr
	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD
Mean food intake (g/rat/day)	29	5	28	6	30	5	29	4	28	6	29	6
Mean BW (g)	712	36	654^a	41	666^a	31	650^a	31	649^a	34	664^a	37
Mean T or EN dose (mg/kg BW/day)					36	9	0.30	0.02	43	8	0.36	0.05
Serum
OC (ng/mL)	175	24	208	54	200	33	123^bd	27	183	32	139^bd	26
ALP (U/L)	175	57	134	38	147	35	194	43	151	28	173	71
CTX-I (ng/mL)	17	3	18	4	19	3	17	1	20	2	17	4
Magnesium (mmol/L)	0.74	0.10	0.68	0.07	0.75	0.08	0.70	0.05	0.77	0.06	0.74	0.07
Calcium (mmol/L)	2.17	0.20	2.06	0.16	2.21	0.22	2.03	0.11	2.28	0.12	2.16	0.14
Phosphor (mmol/L)	1.84	0.26	1.56	0.19	1.69	0.24	1.79	0.22	1.99^b	0.25	2.03^b	0.27
Weights
BW (g)	727	78	642	69	678	122	629	73	659	80	667	105
Levator ani (g)	0.64	0.25	0.31^a	0.08	0.32^a	0.05	0.57^b	0.08	0.37^a	0.11	0.54^b	0.12
Prostata (g)	1.22*	0.30	0.18	0.07	0.19	0.07	0.39	0.08	0.34	0.13	0.62^bcd	0.13
M. gastrocnemius (g)	3.2	0.5	2.8	0.5	3.0	0.6	3.1	0.4	2.9	0.6	2.9	0.6
M. soleus (g)	0.29	0.05	0.27	0.05	0.27	0.03	0.30	0.04	0.26	0.07	0.26	0.06
Biomechanics
Stiffness (N/mm)	75	29	75	32	82	41	66	35	64	28	82	41
Yield load (N)	56	30	44	14	63	17	79	44	57	24	73	42
Microradiography
Dorsal
Ct.Wi.d (mm)	0.58	0.11	0.49	0.17	0.67^b	0.18	0.53	0.08	0.64^b	0.21	0.52	0.10
Ct.Dn.d (%)	99.4	0.5	99.0	1.1	99.5	0.8	98.8	0.8	99.3	0.7	99.2	0.5
Cl.Wi.d (mm)	0.92	0.41	0.70	0.32	0.89	0.48	0.99	0.58	1.1	0.50	0.80	0.43
Cl.Dn.d (%)	67.6	17.5	61.6	16.0	60.2	12.9	52.7^a	13.8	58.2	11.9	65.0	18.0
Endosteal
Cl.Dn.e (%)	88.7	3.9	76.1	10.8	69.6^a	15.1	67.4^a	13.9	70.5^a	14.3	69.9^a	15.9
Fluorescence analysis
The time of the first bridging (day)	27	7	26	9	26	6	34	8	29	9	27	8

*Differs from all other groups

^aDiffers from Non-Orx

^bDiffers from Orx

^cDiffers from Orx+T-pr

^dDiffers from Orx+T-th (Tukey test, p < 0.05)