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Structure-function overview of Factor H-like-1. (A) Comparison of FHL-1 and FH. FH and its splice product FHL-1 share the amino acid sequence and functionalities of the first seven N-terminal complement control protein (CCP) domains. FHL-1 lacks important host recognition properties which are located in the C-terminal CCP domains 19–20 of FH. (B) Impact of individual CCP domains 5, 6 and 7 to CCP 1–4 for binding on C3b, decay accelerating activity (DAA), and cofactor-activity (CA).
