Table 1.
Comparison of FH and FHL-1.
| Property | Protein | Reference | |
|---|---|---|---|
| FH | FHL-1 | ||
| Blood concentration [µM] | ~2-3 | 0.04 (or up to ~1, see text) |
(14, 40–43) |
| ß-phase plasma halftime of human proteins in mice [h] | 18.3 ± 3.7 | 2.9 ± 0.5 | (14) |
| K D for C3b binding [µM] | ~0.6 | ~1 | (13, 14)) |
| Cofactor activity (fluid phase) |
++ | + | (13, 14) |
| Decay accelerating activity (on SPR chip) |
+ | ++ | (13, 14) |
| Sialic acid binding (NMR saturation transfer technique) |
+ | none | (23, 24) |
| IC50 for PNH RBC protection [µM] (when added to FH/FHL-1-depleted serum) |
1.4 ± 0.2 | 2.2 ± 0.5 | (14) |
| IC50 for desialylated PNH RBC protection [µM] (when added to FH/FHL-1-depleted serum) |
3.4 ± 0.8 | 2.2 ± 0.6 | (14) |
| Deregulation by FHR-1 | ++ | 0 to + | (14) |