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. 2020 Oct 15;8:561907. doi: 10.3389/fcell.2020.561907

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Copyright © 2020 Smyth, Patterson, Swan, Maxwell and McKnight.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Manhattan plot showing distribution of delta beta values for uniquely mapped sites across all chromosomes. The blue line discriminates sites that have suggestive differences in methylation between cases with nephropathy compared to non-nephropathic individuals in the control group. Circles above the red line are loci where a substantial difference in beta values (>0.2) were observed and the two markers supported in the replication group are highlighted in green. Markers that are not uniquely mapped to a chromosome position based on Illumina’s updated bead pool manifest are assigned to chromosome 1 in this figure.