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. 2020 Oct 15;11:01320. doi: 10.3389/fphar.2020.01320

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Copyright © 2020 Chen, Zhang, Hu, Zhang, Zhang, Kan, Li and Du

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of SZJ extract on mRNA gene expressions of different subtypes of GABA_A and 5-HT receptors. GraphPad Prism 7.0 software was applied for statistical analysis and graphing. All data were expressed as mean ± SD, and a two-way ANOVA followed by Tukey’s test was applied. Two-way ANOVA analysis results presented that, GABRA1, F (2, 12) =57.27: p < 0.0001; GABRA2, F (2, 12) =112.50: p < 0.0001; GABRA3, F (2, 12) =40.10: p < 0.0001; HTR1A, F (2, 12) =677.80: p < 0.0001; HTR2A, F (2, 12) =13.07: p = 0.0010; HTR1B, F (2, 12) =42.99: p < 0.0001; HTR2B, F (2, 12) =151.50: p < 0.0001. Post hoc Tukey’s test results were represented by comparing with non-H₂O₂ treated control group, ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 and ^****p < 0.0001; compared with H₂O₂ treated control group, ^###p < 0.001 and ^####p < 0.0001.