Table 1.
Clinical characteristics of study subjects (n = 145).
| Variable | n (%) | ||
|---|---|---|---|
| Male | 89 (61.3%) | ||
| Age at diagnosis (years) | 11.2 ± 2.9 | ||
| Anthropometry at diagnosis2, median IQR | CD | UC | p |
| Weight (kg) Weight z score Height (cm) Height z score |
38.4 (30.2–45.8) −0.5 (−1.03–0.01) 150 (137–158) −0.14 (−0.84–0.6) |
42.8 (31.8–53.0) −0.12 (−0.91–0.71) 154 (139.2–161.7) 0.21 (−0.37–1.29) |
0.053 0.096 0.229 0.039 |
| Paris classification | |||
| Ulcerative colitis (n = 48) | |||
| E1 E2 E3 E4 S0 S11 |
7 (15.6%) 6 (13.3%) 9 (20%) 23 (51.1%) 39 (81.2%) 9 (18.8%) |
||
| Crohn's disease (n = 97) | |||
| L3 L3L4a L1 L2 L1L4a L4b L2L4a L4a L3L4ab L3L4b L4ab B1 B2 B3 Perianal disease (p) Growth retardation (G1) |
37 (38.1%) 20 (20.6%) 17 (17.5%) 7 (7.2%) 4 (4.1%) 3 (3.1%) 3 (3.1%) 2 (2.1%) 2 (2.1%) 1 (1.0%) 1 (1.0%) 88 (90.7%) 5 (5.2%) 4 (4.1%) 18 (18.5%) 17 (17.5%) |
||
| Disease activity at diagnosis | |||
| Disease activity UC (PUCAI)3, median (IQR) Mild Moderate Severe |
40 (25–50) 18 (37.5%) 23 (47.9%) 7 (14.6%) |
||
| Disease activity CD (wPCDAI)4, median (IQR) Remission Mild Moderate Severe |
47.5 (39–60) 3 (3.1%) 33 (34%) 30 (30.9%) 31 (32%) |
||
| EIM | 23 (15, 4%) | ||
| Laboratory parameters at diagnosis | CD | UC | P |
| Faecal calprotectin (μg/g) | 500 (291–880) | 500 (304–1,450) | 0.405 |
| CRP (mg/dl) | 2.31 (0.8–7.0) | 0.5 (0.2–1.7) | 0.0001 |
| ESR (mm/h) | 36 (22–62) | 24 (8–41) | 0.004 |
| Hb (g/dl) | 11.5 (10.6–12.2) | 11.8 (9.6–13.1) | 0.818 |
| Htc (%) | 35.4 (33.0–38.0) | 34.5 (30.1–40.7) | 0.877 |
| Platelets (×109/L) | 477 (376–573) | 379 (298–481) | 0.001 |
| Orosomucoid (mg/L) | 234 (145–304) | 105 (78–124) | 0.13 |
PUCAI ≥65 points.
Reference values (16). Paris classification was adapted from Levine et al. (13). EIM, extraintestinal manifestations.
PUCAI, Paediatric Ulcerative Colitis Index; Remission <10; Mild 10–34; Moderate 35–64; Severe ≥65 points. From reference (15).
wPCDAI, weighted Pediatric Crohn's Disease Activity Index; Remission <12.5; Mild 12.5–40; Moderate >40; Severe >57.5 points. From reference (14); CD, Crohn's disease; UC, ulcerative colitis; CRP, C-reactive protein; Hb, hemoglobin; Htc, hematocrit; ESR, Erythrocyte sedimentation rate; EIM, extraintestinal manifestations; IQR, Interquartile range. The four patients with inflammatory bowel disease unclassified were excluded from the analysis.