Table 2.
Inhibition of miR-222 Improves Glucose Metabolism of the PCOS Rats
| Group | IAA (μg/mL) | ICA (μg/mL) | GAD (g/L) | BG120min (mmol/L) | INS120min (mU/L) |
|---|---|---|---|---|---|
| Normal | 0.18 ± 0.08a | 0.12 ± 0.06a | 0.17 ± 0.08a | 5.08 ± 0.47a | 11.51 ± 1.12a |
| Model | 1.34 ± 0.12b | 1.25 ± 0.09b | 1.31 ± 0.11b | 6.12 ± 0.51b | 21.12 ± 2.05b |
| NC | 1.31 ± 0.11b | 1.24 ± 0.08b | 1.33 ± 0.12b | 6.15 ± 0.52b | 22.91 ± 2.07b |
| miR-222 agomir | 2.47 ± 0.18c | 2.81 ± 0.21c | 3.71 ± 0.26c | 6.79 ± 0.56c | 29.99 ± 2.73c |
| miR-222 antagomir | 0.16 ± 0.06a | 0.11 ± 0.06a | 0.18 ± 0.09a | 5.11 ± 0.49a | 12.57 ± 1.09a |
| miR-222 agomir + empty vector | 2.45 ± 0.16c | 2.84 ± 0.22c | 3.74 ± 0.27c | 6.81 ± 0.58c | 28.11 ± 2.75c |
| miR-222 agomir + Pten | 1.36 ± 0.13a | 1.27 ± 0.07a | 1.35 ± 0.14a | 6.18 ± 0.47a | 21.98 ± 2.01a |
IAA, insulin autoantibody; ICA, islet cell antibody; GAD, glutamic decarboxylase antibody; BG, blood glucose; INS, insulin; NC, negative control.
a
compared with the Model group P < 0.05.
b
compared with the Normal group P < 0.05.
c
compared with the NC group P < 0.05.