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. 2020 Oct 15;8:568889. doi: 10.3389/fcell.2020.568889

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Copyright © 2020 Gharbi, Zhang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Astrocytes and surrounding cells in the microenvironment regularly communicate and interact with each other via exosomes. Cells may use astrocytes to exert their effects. For instance, BM-derived stem cells miR-138-5p-overexpressing exosomes prevent astrocytes from apoptosis after ischemic stroke by targeting lipocalin 2 or high level of miR-133b in astrocytes can down-regulate the expression of CTGF, which cause glial scar reduction and further increase the recovery post-ischemic stroke.