Table 1.

Validation Experiments for the Parallel Synthesis of Libraries 11–15

#	Method	Conditions	Library	Success Rate, %a	Average Yield, %
					All Experiments	Successful Experiments
1	A	1. HATU, i-Pr2NEt, DMSO, rt, 16 h 2. CF3COOH, i-Pr3SiH, H2O, rt, 6 h 3. HATU, i-Pr2NEt, DMSO, rt, 16 h	11	77	34	44
2	B	1-2. Same as for A 3. i-Pr2NEt, NMP,b 100°C, 16 h	12	60	26	43
3	C	1-2. Same as for A 3. i-Pr2NEt, DMF, 80°C, 16 h	13	53	16	31
4	D	1. i-Pr2NEt, NMP,b 100°C, 16 h 2-3. Same as for A	14	81	30	38
5	E	1. HATU, i-Pr2NEt, DMF, rt, 16 h 2. i-Pr2NEt, Cu(OAc)2, 80°C, 16 h	15	80	41	51

See Also Tables S1 and S2, Figures S1 and S2.

^aFraction of 400 experiments that allowed for the preparation of the target product.

^bNMP, N-methyl-2-pyrrolidone.