Table 2.
# | Method | Reagents | Number of Synthons |
||
---|---|---|---|---|---|
No Reactivity Features | With Steric Features | Total | |||
1 | A | 1 | 467 | 196a | 663 |
2 | 4 | 6,706 | 1,271 | 7,977 | |
3 | 5 | 5,451 | 1,063 | 6,514 | |
4 | E | 2 | 41 | 0 | 41 |
5 | 3 | 52 | 0 | 52 | |
6 | 8 | 17,944 | 550 | 18,494 | |
7 | 9 | 26,434 | 646 | 27,080 | |
8 | 10 | 807 | 0 | 807 |
With steric hindrance at the free amino group (103), the protected amino group (82), or both (11).