Table 5.

Fractions of the Generated Chemical Space (%) Compliant with the Drug- and Lead-likeness Rules

#	Method	Rule of 5a	+ Veber's Rulesb	Rule of 4.5c	Rule of 4d	Churcher's Rulese,f
1	A	89.1	82.6	56.9	16.9	0.08 (21,167,934)
2	E	48.4	40.4	24.3	7.4	0.06 (952,402)
3	Total	86.9	80.3	55.1	16.5	0.08 (22,120,336)

^aMW < 500, LogP<5, HAcc≤10, HDon≤5 (Lipinski et al., 1997).

^bRotB ≤10, TPSA <140 (Veber et al., 2002).

^cMW < 450, LogP<4.5 (Oprea et al., 2001).

^dMW < 400, LogP<4 (Hann and Oprea, 2004).

^eMW 200 … 350, LogP −1 … 3 (Nadin et al., 2012).

^fAbsolute numbers of the library members are given in brackets.