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. 2020 Oct 15;8:584181. doi: 10.3389/fcell.2020.584181

FIGURE 1.

FIGURE 1

The main receptors involved in the formation and activities of invadopodia. Schematic illustration of the main cellular receptors driving invadopodia in cancer cells: (A) The family of tyrosine kinase receptors includes epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor α (PDGFRα), Tyrosine-Protein Kinase Met (Met); (B) The family of G-protein-coupled receptors (GPCR) includes lysophosphatidic acid receptors (LPAR), endothelin-1 receptors (ET-1R), kisspeptin receptors (KISS1R), C-X-C Motif Chemokine Receptor 4 (CXCR4), C-C Motif Chemokine Receptor 3 (CCR3); (C) The transforming growth factor β (TGFβ) receptors family includes TGFβR1 and TGFβR2; (D) The family of integrins includes the β1 and β3 subunits. The plot was created using BioRender (app.biorender.com).