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. 2020 Oct 15;8:589136. doi: 10.3389/fcell.2020.589136

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Copyright © 2020 Vesela, Kratochvilova, Svandova, Benes, Rihova, Poliard and Matalova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Caspase-12 protein in perinatal and postnatal development. Immunofluorescence analysis of caspase-12 (green) in mandibular bone and the first lower molar at perinatal stages (E18 and P1) and postnatal stage P12. Caspase-12 was localized in the mandibular bone, predominantly in osteoblasts (A,C,E) at all of these stages. In the developing tooth, caspase-12 was positive mainly in ameloblasts and odontoblasts (B,D,F). Scale bar: 100 μm, counterstained by DAPI (blue). White arrows point to osteoblasts, a red arrow points to osteoclasts. mb, mandibular bone; si, stratum intermedium; sr, stellate reticulum; dp, dental pulp; am, ameloblasts; od, odontoblasts.