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. 2020 Oct 15;8:589136. doi: 10.3389/fcell.2020.589136

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Copyright © 2020 Vesela, Kratochvilova, Svandova, Benes, Rihova, Poliard and Matalova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of caspase-12 in osteoblasts. Comparison of serial sections of the mouse mandibular bone at the prenatal/embryonic (E) day 15 showing co-localization of caspase-12 (A) with osteoblastic markers osteocalcin (B) and Runx2 (C) within the bone. Positive cells are brown, counterstained by hematoxylin (blue). Arrows point to cells in the same region. Scale bar: 50 μm. Expression of caspase-12 in undifferentiated and differentiated MC3T3-E1 cells (D) showing stable expression of Casp12 after 21 days of differentiation. Western blot analysis (E) and immunofluorescence (F) confirmed the presence of caspase-12 protein in MC3T3-E1. E: 55 kDa-full length caspase-12, 42 kDa-cleaved caspase-12, DMSO: caspase-12 forms after DMSO treatment, C12 INH: caspase-12 forms after specific inhibitor treatment. F: Caspase-12 in green, DAPI in blue. Scale bar: 100 μm.