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. 2020 Oct 15;8:589136. doi: 10.3389/fcell.2020.589136

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Copyright © 2020 Vesela, Kratochvilova, Svandova, Benes, Rihova, Poliard and Matalova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene silencing of Casp12 in MC3T3-E1. Gene silencing of Casp12 in MC3T3-E1 cells using specific siRNA showed statistically significant reduction of Casp12 expression (A). Real-time PCR confirmed statistically significant decrease in expression of Alpl (D), Bglap (E), Phex (F), and Dmp1 (G) after Casp12 silencing. Results are presented as means ± standard deviations and were analyzed using two-tailed t-test. Immunofluorescence detection of caspase-12 (green) protein in MC3T3-E1 after Casp12 gene silencing (B) compared to control (C), DAPI in blue.