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. 2020 Oct 15;10:554331. doi: 10.3389/fonc.2020.554331

FIGURE 4.

FIGURE 4

High CHST4 expression is related to better prognoses in patients with hepatitis B virus-related hepatocellular carcinoma (HBV-HCC). (A) Expression of CHST4 in patients from the GSE14520 dataset. (B) mRNA expression of CHST4 in 40 paired HCC and normal tissue samples (N/C) by qRT-PCR assays. All samples were tested in triplicate. The statistical analysis is paired-samples t-test. Bars represent the mean ± SD. (C) Representative staining of low and high CHST4 expression in the tumor cell cytoplasm. (D,F). Kaplan–Meier analysis of overall survival and disease-free survival in those with high CHST4 expression in the GSE14520 dataset versus low expression. (E) Receiver-operating characteristic curves (ROC) of the prognostic accuracy of CHST4 expression and clinicopathological risk factors of patients in the GSE14520 dataset. Comparative ROC curves for CHST4 expression, Barcelona Clinic Liver Cancer (BCLC) stage, and BCLC stage with two factors (multinodular and cirrhosis) or with four factors (CHST4 expression, BCLC stage, multinodular, and cirrhosis) are shown (AUC, area under the curve).