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Enzyme inhibitory activity of FNA compared with MS275 and SAHA (IC50, nM)a.
| HDACs | HDAC1 | HDAC2 | HDAC3 | HDAC4 | HDAC6 | HDAC7 | HDAC8 | HDAC9 |
|---|---|---|---|---|---|---|---|---|
| FNA | 842.80 | 949.15 | 95.48 | >5,000 | >5,000 | >5,000 | >5,000 | >5,000 |
| MS275 | 46.17 | 100.90 | 43.89 | >5,000 | >5,000 | >5,000 | >5,000 | >5,000 |
| SAHA | 52.90 | 90.78 | 167.24 | >5,000 | 172.10 | >5,000 | 4,120 | >5,000 |
Assays were performed in replicate (n ≥ 2), the SD values are <10% of the mean.
