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. 2020 Oct 15;10:583228. doi: 10.3389/fonc.2020.583228

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Copyright © 2020 Crotti, Fraccaro, Bedin, Bertazzo, Di Marco, Pucciarelli and Agostini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRP and its key catabolites (TRYCATs) produced via three biochemical pathways: the kynurenine pathway, tryptamine pathway, and serotonin pathway. Enzymes involved: AADC, aromatic L-amino acid decarboxylase; AD, aldehyde dehydrogenase; 3-HAAO, 3-hydroxyanthranilate 3,4-dioxygenase; IDO1, indoleamine-2,3-dioxygenases 1; IDO2, indoleamine-2,3-dioxygenases 2; KAT, L-kynurenine aminotransferase; KMO, kynurenine monooxygenase; MAO-A, monoamine oxidase A; TDO, tryptophan-2,3-dioxygenase; TPH1, tryptophan hydroxylase 1.