Table 4.

Normalized (tumor/healthy mucosa) gene expression (nRQ) after patients' stratification according to their TRG (responders: TRG 1–2; nonresponders: TRG 3–5).

	TRG 1–2 (n = 6 pairs)		TRG 3–5 (n = 7 pairs)
	Mean	Min, max	Mean	Min, max	Trend in TRG 3–5
IDO1 (nRQ)	0.66	0.13, 2.00	0.789	0.10, 2.41	=
TDO2 (nRQ)	0.88	0.40, 1.99	2.13	0.09, 10.04	↑
Calculated activity	136	8.6, 292.5	311	11.6, 636.6	↑
TPH1 (nRQ)	0.19	0.002, 0.44	0.66	0.001, 3.65	↑
Calculated activity	43	1.2, 149	29	2.6, 94.7	=

Data are presented as mean fold change and minimum and maximum (Min, Max) values. “Trend in tumor” column highlights fold changes at least >1.5 (or <0.67). Enzymatic activity is reported as calculated mean value for rectal cancer samples (healthy mucosa) and relative minimum and maximum.