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. 2020 Oct 15;11:584241. doi: 10.3389/fimmu.2020.584241

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Copyright © 2020 Borghi, Beltagy, Garrafa, Curreli, Cecchini, Bodio, Grossi, Blengino, Tincani, Franceschini, Andreoli, Lazzaroni, Piantoni, Masneri, Crisafulli, Brugnoni, Muiesan, Salvetti, Parati, Torresani, Mahler, Heilbron, Pregnolato, Pengo, Tedesco, Pozzi and Meroni

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Titers of aCL and aβ₂GPI antibodies detected by ELISA in COVID-19 patients (black, n = 122) and comparison with APS patients (green, n = 86). Values are expressed as median levels [first and third quartile]. (A) aCL. From the left to the right: COVID-19 IgG: 15 [8–15]; APS IgG: 65 [22–103]; COVID-19 IgM: 6.2 [2.6–10.8]; and APS IgM: 4.0 [1–11]. (B) aβ₂GPI. From the left to the right: COVID-19 IgG: 0.06 [0.04–0.10]; APS IgG: 1.14 [0.52–1.55]; COVID-19 IgM: 0.065 [0.02–0.142]; APS IgM: 0.23 [0.105–0.741]; and COVID-19 IgA: 0.04 [0.02–0.09]. Cutoff values are aCL IgG/IgM 20 phospholipid units (GPL/MPL); aβ₂GPI IgG/IgM/IgA ELISA 0.13, 0.27, and 0.16 optical units (OD), respectively.