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. 2020 Oct 15;11:571334. doi: 10.3389/fimmu.2020.571334

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Copyright © 2020 Fischer, Tschismarov, Pilz, Straubinger, Carotta, McDowell and Decker

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intracellular survival of C. acnes and L.m. in human macrophages deficient for either MyD88, TRIF, IRF9, or STING. Colony-forming-unit (CFU) assay was performed using PMA-differentiated THP-1 cells deficient for either MyD88, TRIF, IRF9, or STING. THP-1 cells were either infected with C. acnes strain NCTC737 (A) or L.m. (B) for indicated timepoints. Graphs show the standard deviation and mean of three independent experiments. Unpaired t-test of log transformed values was calculated. P-values (*P ≤ 0.05).