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Effect of β-hydroxybutyrate (β-OHB) (A), Iron (B) and ROS removal (A) on stimulation of insulin secretion (A) and ROS generation (B) in clonal pancreatic β-cells (Adimora et al., 2010; Go and Jones, 2010b). Panel A shows insulin secretion at basal glucose in response to 20 mM β-OHB and concentration-dependent reversal with increasing NAC (n-acetyl cysteine). Panel B shows concentration-dependent ROS production from iron at basal and stimulatory glucose.
