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Effect of saccharin on ROS production in clonal pancreatic β-cells (A) and human adipocytes (B). A, Dark circles are vehicle, light circles are 5 mM saccharin. B, Concentration-dependent ROS production in cultured, differentiated human adipocytes in response to increasing concentrations of saccharin. The positive controls are tert-butyl hydroperoxide (t-BOOH) with and without 10 mM saccharin.
