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. 2020 Apr 6;11(4):455–490. doi: 10.1039/d0md00062k

Table 2. In vitro schistosomicidal activity of neo- and norneocryptolepine derivatives on adult S. mansoni worms161.

Inline graphic
Compound R R1 R2 Worm mortality (%) IC50 (μM)
 IC90 (μM)
Egyptian strain Puerto Rican strain Egyptian strain Puerto Rican strain
145 2-Cl Me NHCH(Me)(CH2)3NEt2 100 11.74 14.98 16.78 21.65
146 3-Cl Me NHCH(Me)(CH2)3NEt2 100 19.26 29.33 24.32 32.83
147 2-Cl Me graphic file with name d0md00062k-u2.jpg 100 1.26 3.54 4.05 6.83
148 2-Cl Me graphic file with name d0md00062k-u3.jpg 100 1.77 3.29 4.55 5.57
149 2-Cl Me NH(CH2)2NMe2 100 3.68 5.95 7.65 13.03
150 2-Cl Me graphic file with name d0md00062k-u4.jpg 100 3.46 7.85 8.31 13.39
151 2-Cl — graphic file with name d0md00062k-u5.jpg 100 5.41 6.27 13.68 17.95
152 2-Cl — graphic file with name d0md00062k-u6.jpg 100 3.41 7.61 6.30 11.02