Table 4. Antischistosomal properties of some promising compounds.

Compound a	Species	Life cycle stage	In vitro b (μM)	In vivo c (% WBR)	Morphological effect (≤100 μM in ≤72 h)				Enzyme inhibition (IC50, μM)
					Worm death (%)	Tegument damage d (%)	Motor activity d (%)	Egg d (% reduction)
155 162	S. mansoni	Adult	53.5		100	25	100
156 163,164	S. mansoni	Juvenile		50.2
		Adult		70.0	100	100	100	80.0
157 165,166	S. mansoni	Juvenile		58.0
		Adult		60.6	100	100	100	64.1
158 167	S. mansoni	Adult			100	100	100
159 168	S. mansoni	Larva		88.6
		Juvenile		68.3
		Adult		70.6
	S. japonicum	Larva		90.0
		Juvenile		59.9
		Adult		53.2
160 169	S. mansoni	Adult			100	Y	EC50 = 8.8 μM	EC50 = 3.6 μM	SmAChE e
161 170	B. glabrata	Snail	1.2
162 171	S. mansoni	Miracidia			99.7
		Cercariae			41.0
163 172,173	S. mansoni	Adult		81.2	100	20	100	54–67	SmTGR
164 174	S. japonicum	Larva	12.8
		Adult	15.6	Y
165 175	S. mansoni	Adult			83.3	Y	Y	Y
166 176	S. mansoni	Larva	2.6						SmTGR
		Adult	4.9
167 177	S. mansoni	Larva	13.9
		Adult			100			Y
168 178	S. mansoni								rSmNACE f (2.2)
									nSmNACE g (20)
169 179	S. mansoni	Adult	47.9			Y
170 180	S. mansoni	Adult			100				SmTGR

^aReference.

^bIC₅₀/LC₅₀.

^cTotal worm burden reduction.

^dSignificant effect observed.

^e S. mansoni acetylcholinesterase.

^fRecombinant S. mansoni NAD catabolizing enzyme.

^gNative S. mansoni NAD catabolizing enzyme.