TABLE 2.

Comparison of the sequences and diversity across 7 variable regions of TprK

Parameter	No. of strains	Total no. of variable region sequences		Total no. of full-length TprK sequences		Total diversity
		Median (range)	P value	Median (range)	P value	Median (range)	P value
Stage
Primary	7	39 (30–59)	0.002	22 (11–26)	0.003	2.01 (0.78–3.93)	0.005
Secondary	6	90 (54–135)		80 (35–133)		6.21 (3.39–9.08)
HIV status
Positive	8	73.5 (39–135)	0.045	48 (14–133)	0.272	3.92 (2.01–9.08)	0.171
Negative	5	36 (30–59)		26 (11–37)		1.91 (0.78–6.48)
Lesion location
Genital	7	43 (30–82)	0.138	26 (11–99)	0.224	2.01 (0.78–4.46)	0.022
Anal	6	76 (39–135)		49 (14–133)		6.21 (3.29–9.08)
Infection status
First time infected	9	54 (30–116)	0.604	26 (11–133)	0.38	3.39 (0.78–9.08)	0.604
Previous infection	4	62.5 (39–135)		43 (17–99)		3.92 (2.01–8.45)
Passaged in rabbits
Yes	2a	199.5 (161–238)	0.019	243 (146–340)	0.034	12.04 (8.76–15.33)	0.038
No	13	54 (30–135)		26 (11–133)		3.39 (0.78–9.08)

^aIsolates were previously profiled by Addetia et al. (23).