Table 1.
Characteristics of the studies included in Section 1 for flavonols subclass (see Table S1 for all 9 subclasses).
| Flavonol | Disease | In Vitro Tests | In/Ex Vivo Tests | Author, Year |
|---|---|---|---|---|
| Beturetol | Angiogenesis | CAM | Hisanori Hattori, 2011 [18] | |
| Casticin | Cancer * | Shanaya Ramchandani, 2020 [19] | ||
| Denticulatain | Lung Cancer | ZFM | Da Song Yang, 2015 [20] | |
| Dihydrokaempferide | Angiogenesis | CAM | Hisanori Hattori, 2011 [18] | |
| Fisetin | Cancer * | Dharambir Kashyap, 2018 [21] | ||
| Cancer * | Thamaraiselvan Rengarajan, 2016 [22] | |||
| Cancer * | Deeba N.Syed, 2016 [23] | |||
| Cancer * | Lall K. Rahul, 2016 [24] | |||
| Breast Cancer | In | Cheng Fang Tsai, 2018 [25] | ||
| Breast Cancer | WH, In | Xu Sun, 2018 [26] | ||
| Breast Cancer | WH, In | Mets in mice | Jie Li, 2018 [27] | |
| Cervical Cancer | In | Ruey Hwang Chou, 2013 [28] | ||
| Glioma | In | Chien Min Chen, 2015 [29] | ||
| Hepatic Cancer | In | Xiang Feng Liu, 2017 [30] | ||
| Leukemia | In | Anna Klimaszewska-Wiśniewska, 2019 [31] | ||
| Lung Cancer | WH, In | Saba Tabasum, 2019 [32] | ||
| Lung Cancer | WH, In, Ad | Junjian Wang, 2018 [33] | ||
| Prostate Cancer | WH, In, Ad | Chi Sheng Chien, 2010 [34] | ||
| Renal Cancer | In | Yih Shou Hsieh, 2019 [35] | ||
| Retinopathy | RbCN | A M Joussen, 2000 [36] | ||
| Galangin | Hepatic Cancer * | Dengyang Fang, 2019 [37] | ||
| Angiogenesis | TF, Ad | Jong Deog Kim, 2006 [38] | ||
| Glioma | TF, In | CAM, MD in mice | Daliang Chen, 2019 [39] | |
| Glioma | In | Deqiang Lei, 2018 [40] | ||
| Hepatic Cancer | WH, In, Ad | Shang Tao Chien, 2015 [41] | ||
| Ovarian Cancer | TF | CAM | Haizhi Huang, 2015 [42] | |
| Renal Cancer | WH, In | Jingyi Cao, 2016 [43] | ||
| Renal Cancer | In | Yun Zhu, 2018 [44] | ||
| Gossypin | Gastric Cancer | In | Wang Li, 2019 [45] | |
| Herbacetin | Melanoma | In | Lei Li, 2019 [46] | |
| Hyperoside | Arthritis | WH, In | CIAM in mice | Xiang Nan Jin, 2016 [47] |
| Icariin | Bone disease * | Xin Zhang, 2014 [48] | ||
| Cancer * | Meixia Chen, 2016 [49] | |||
| Angiogenesis | TF, In | RAR | Byung Hee Chung, 2008 [50] | |
| Esophageal Cancer | In | Zhen Fang Gu, 2017 [51] | ||
| Ovarian Cancer | WH | Pengzhen Wang, 2019 [52] | ||
| Wound healing | EWM in rats | Wangkheirakpam Ramdas Singh, 2019 [53] | ||
| Icariside | Cancer * | Meixia Chen, 2016 [49] | ||
| Glioma | WH, In | Kai Quan, 2017 [54] | ||
| Isoviolanthin | Hepatic Cancer | WH, In | Shangping Xing, 2018 [55] | |
| Isosakuranetin | Angiogenesis | CAM | Hisanori Hattori, 2011 [18] | |
| Kaempferol | Cancer * | Allen Y. Chen, 2013 [56] | ||
| Cancer * | Dharambir Kashyap, 2017 [57] | |||
| Angiogenesis | WH, TB, In | Hsien Kuo Chin, 2018 [58] | ||
| Angiogenesis | WH, TB | ZFM | Fang Liang, 2015 [59] | |
| Angiogenesis | CAM | Shigenori Kumazawa, 2013 [60] | ||
| Angiogenesis | TF, Ad | Jong Deog Kim, 2006 [38] | ||
| Diabetes | EWM in rats | Yusuf Özay, 2019 [61] | ||
| Glioma | WH | Vivek Sharma, 2007 [62] | ||
| Glioma | In | Mets in mice | S.C. Shen, 2006 [63] | |
| Hepatic Cancer | WH, In | Mets in mice | Youyou Qin, 2015 [64] | |
| Hepatic Cancer | In | Genglong Zhu, 2018 [65] | ||
| Lung Cancer | WH, In | Eunji Jo, 2015 [66] | ||
| Medulloblastoma | Ad | David Labbé, 2009 [67] | ||
| Oral Cancer | In | Chiao Wen Lin, 2013 [68] | ||
| Osteosarcoma | WH, In, Ad | Hui Jye Chen, 2013 [69] | ||
| Ovarian Cancer | CAM | Haitao Luo, 2009 [70] | ||
| Pancreatic Cancer | In | Jungwhoi Lee, 2016 [71] | ||
| Renal Cancer | WH, In | Mets in mice | Tung Wei Hung, 2017 [72] | |
| Retinal Vascularization | WH, In | Hsiang Wen Chien, 2019 [73] | ||
| Kaempferol-3-O-[(6-caffeoyl)-β- glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside | Angiogenesis | WH | Marco Clericuzio, 2012 [74] | |
| Kaempferide | Angiogenesis | CAM | Hisanori Hattori, 2011 [18] | |
| Morin | Arthritis | WH, TB | CIAM in rats | Ni Zeng, 2015 [75] |
| Arthritis | WH, TB | CIAM in rats | Mengfan Yue, 2018 [76] | |
| Leukemia | Ad | Nagaja Capitani, 2019 [77] | ||
| Melanoma | WH | Hua Wen Li, 2016 [78] | ||
| Myricetin | Melanoma * | Nam Joo Kang, 2011 [79] | ||
| Angiogenesis | TF, Ad | Jong Deog Kim, 2006 [38] | ||
| Breast Cancer | In | CAM, MD in mice, RAR | Zhiqing Zhou, 2019 [80] | |
| Breast Cancer | WH, In, Ad | Mets in mice | Yingqian Ci, 2018 [81] | |
| Glioma | WH, In | Wen Ta Chiu, 2010 [82] | ||
| Hepatic Cancer | In | Noriko Yamada, 2020 [83] | ||
| Hepatic Cancer | WH, In | Hongxin Ma, 2019 [84] | ||
| Lung Cancer | WH, In, Ad | Yuan Wei Shih, 2009 [85] | ||
| Medullobalstoma | In, Ad | David Labbé, 2009 [67] | ||
| Ovarian Cancer | TF | CAM | Haizhi Huang, 2015 [42] | |
| Quercetin | Breast Cancer * | Maryam Ezzati, 2020 [86] | ||
| Cancer * | Si-min Tang, 2020 [87] | |||
| Cancer * | Dharambir Kashyap, 2016 [88] | |||
| Colorectal Cancer * | Saber G. Darband, 2018 [89] | |||
| Angiogenesis | WH, In | Nu Ry Song, 2014 [90] | ||
| Angiogenesis | WH, TB | ZFM | Chen Lin, 2012 [91] | |
| Angiogenesis | TF, Ad | Jong Deog Kim, 2006 [38] | ||
| Bladder Cancer | WH, In | Yu Hsiang Lee, 2019 [92] | ||
| Breast Cancer | WH | Divyashree Ravishankar, 2015 [93] | ||
| Breast Cancer | MD in mice | Xin Zhao, 2016 [94] | ||
| Breast Cancer | CAM | Soo Jin Oh, 2010 [95] | ||
| Breast Cancer | WH, In | Asha Srinivasan, 2016 [96] | ||
| Breast Cancer | WH, In | Cheng Wei Lin, 2008 [97] | ||
| Breast Cancer | In | Amilcar Rivera Rivera, 2016 [98] | ||
| Cancer | TF | ZFM | Daxian Zhao, 2014 [99] | |
| Cancer | TF, In | CAM | Wen Fu Tan, 2003 [100] | |
| Cancer | MD in mice | Xiangpei Zhao, 2012 [101] | ||
| Cancer | WH, In | Lung Ta Lee, 2004 [102] | ||
| Cancer | WH | Dong Eun Lee, 2013 [103] | ||
| Colorectal Cancer | WH, In | Mets in mice | Ji Ye Kee, 2016 [104] | |
| Glioma | WH | Hong Chao Pan, 2015 [105] | ||
| Glioma | WH, In | Wen Ta Chiu, 2010 [82] | ||
| Glioma | WH, In | Yue Liu, 2017 [106] | ||
| Glioma | In | Jonathan Michaud-Levesque, 2012 [107] | ||
| Glioma | WH | Alessandra Bispo da Silva, 2020 [108] | ||
| Glioma | WH, TB, In | Yue Liu, 2017 [109] | ||
| Hepatic Cancer | In | Noriko Yamada, 2020 [83] | ||
| Hepatic Cancer | WH, In | Jun Lu, 2018 [110] | ||
| Lung Cancer | WH | Anna Klimaszewska-Wiśniewska, 2017 [111] | ||
| Lung Cancer | In | Tzu Chin Wu, 2018 [112] | ||
| Lung Cancer | In | Yo Chuen Lin, 2013 [113] | ||
| Medulloblastoma | In, Ad | David Labbé, 2009 [67] | ||
| Melanoma | In | Mun Kyung Hwang, 2009 [114] | ||
| Melanoma | In | Hui Hui Cao, 2015 [115] | ||
| Melanoma | WH, In | Mets in mice | Hui Hui Cao, 2014 [116] | |
| Oral Cancer | In | Junfang Zhao, 2019 [117] | ||
| Osteoblasts | In | Tae Wook Nam, 2008 [118] | ||
| Osteosarcoma | WH, In, Ad | Shenglong Li, 2019 [119] | ||
| Osteosarcoma | WH, In | Mets in mice | Haifeng Lan, 2017 [120] | |
| Osteosarcoma | WH, Ad | Kersten Berndt, 2013 [121] | ||
| Pancreatic Cancer | WH, In | Ying Tang Huang, 2005 [122] | ||
| Pancreatic Cancer | WH, In | Yu Dinglai 2017 [123] | ||
| Prostate Cancer | WH, In | Firdous Ahmad Bhat, 2014 [124] | ||
| Prostate Cancer | TF, In | MD in mice | Feiya Yang, 2016 [125] | |
| Retinoblastoma | In | Wei Song, 2017 [126] | ||
| Quercetin-3-O-[(6-caffeoyl)-β-glucopyranosyl(1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside | Angiogenesis | WH | Marco Clericuzio, 2012 [74] | |
| Rutin | Angiogenesis | CAM | César Muñoz Camero, 2018 [127] | |
| Angiogenesis | CAM | Shigenori Kumazawa, 2013 [60] | ||
| Cancer | WH, In, Ad | Mohamed ben Sghaier, 2016 [128] | ||
| Glioma | WH | Alessandra Bispo da Silva, 2020 [108] | ||
| Neuroblastoma | WH, In | Hongyan Chen, 2013 [129] | ||
* Review article; TB, Tube Formation; WH, Wound Healing; In, Invasion; Ad, Adhesion; Mets, Metastasis; CAM, Chick Chorioallantoic Membrane; MPA, Matrigel Plug Assay; RAR, Rat Aortic Ring; EWM, Excision Wound Model; SF, Skin Flap; RRN, Rat Retinal Neovascularization; MAR, Mice Aortic Ring; MD, Microvessel Density; MRN, Mice Retinal Neovascularization; MCN, Mice Corneal Neovascularization; RbCN, Rabbit Corneal Neovascularization; ZFM, Zebra Fish Model; RCN, Rat Corneal Neovascularization; CIAM, Collagen Induced Arthritis Model; DASM, Dorsal air Sac Model; IWM, Incision Wound Model.