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. 2020 Oct 11;25(20):4626. doi: 10.3390/molecules25204626

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Flavonoids have beneficial effects on treating peptic ulcer via antioxidative activity. Flavonoids increase the activities of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione (GSH). and the nuclear Nrf2 level to exert gastroprotective effects through scavenging reactive oxygen species (ROS) and up-regulating the phase II detoxification and antioxidant genes HO-1.2.4 Flavonoids ameliorate peptic ulcer by regulating inflammatory pathways.