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. 2020 Oct 12;25(20):4630. doi: 10.3390/molecules25204630

Table 1.

SAR studies of 2-substitutions on the thiazolo[5,4-b]pyridine.

Compd X R1 R2 cLogP a PSA a PI3Kα (nm) b
19a N OMe graphic file with name molecules-25-04630-i001.jpg 4.1 105.0 3.6
19b N OMe graphic file with name molecules-25-04630-i002.jpg 4.4 105.0 4.6
19c N OMe graphic file with name molecules-25-04630-i003.jpg 4.3 105.0 8.0
19d N OMe Me 2.1 105.0 53
19e CH OMe graphic file with name molecules-25-04630-i004.jpg 4.4 92.6 501
19f N H graphic file with name molecules-25-04630-i005.jpg 3.3 95.7 4.0

a Calculated from ChemBioDraw Ultra 14.0. b Mean of at least three separate experiments.