Scheme 1.
Reagents and conditions. (i) Aromatic amine, DIBAL-H, dry THF, rt (room temperature), 3–5 h; (ii) Aliphatic amine, dry THF, 45 ºC, 48 h; (iii) NaOH, MeOH, rt, 2 h; (iv) R1-Br, K2CO3, dry DMF, rt, 24 h; (v) MeOH, 45 °C, 72 h.
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