Table II.

Descriptive Statistics for Metabolite Profiles: TGN and MMP Absolute Values and Dosing Recommendations (M ± SD), Range or n (%)

Timepoint	High TGN - low MMP				Low TGN - High MMP				Low TGN - Low MMP
	6-TGN	6-MMP	Within or above Recommendations	Below Recommendations	6-TGN	6-MMP	Within or above Recommendations	Below Recommendations	6-TGN	6-MMP	Within or above Recommendations	Below Recommendations
Baseline	1,386 ± 535	6,238 ± 5,143	23 (88.5)	3 (11.5)	585 ± 229	30,832 ± 10,756	58 (100)	0 (0)	381 ± 215	5,598 ± 4,939	44 (80)	11 (20)
	(860–3,233)	(0–18,609)			(232–1,482)	(15,027–74,494)			(0–811)	(0–17,755)
3 months	1,345 ± 536	5,100 ± 4,151	16 (94.1)	1 (5.9)	580 ± 218	30,100 ± 11,453	53 (98.1)	1 (1.9)	449 ± 218	6,206 ± 5,088	57 (91.9)	5 (8.1)
	(844–2,647)	(122–14,734)			(249–1,141)	(15,660–82,130)			(0–831)	(0–17,459)
6 months	1,292 ± 332	7,066 ± 6,098	18 (94.7)	1 (5.3)	535 ± 189	28,831 ± 10,248	59 (100)	0 (0)	437 ± 194	6,786 ± 5,212	49 (90.7)	5 (9.3)
	(881–2,248)	(116–23,707)			(253–1,102)	(15,356–65,568)			(0–794)	(0–17,380)
9 months	1,189 ± 367	6,578 ± 4,534	20 (100)	0 (0)	586 ± 236	32,821 ± 11,441	53 (98.1)	1 (1.9)	417 ± 203	7,709 ± 5,468	53 (93)	4 (7.0)
	(844–2,178)	(226–14,934)			(198–1,123)	(14,682–62,171)			(0–766)	(0–17,494)
12 months	1,175 ± 366	8,635 ± 8,854	17 (100)	0 (0)	562 ± 213	28,498 ± 9,868	62 (100)	0 (0)	414 ± 173	5,954 ± 4,655	35 (85.4)	6 (14.6)
	(846–1,957)	(230–30,263)			(209–1,008)	(16,199–60,967)			(115–775)	(123–17,187)
15 months	1,277 ± 484	4,388 ± 5,551	14 (100)	0 (0)	580 ± 175	30,301 ± 9,895	53 (100)	0 (0)	386 ± 198	5,234 ± 4,231	40 (93)	3 (7)
	(873–2,551)	(156–17,299)			(266–1,006)	(17,173–56,040)			(0–792)	(0–15,709)
Overall mean	1284 ± 445	6,398 ± 5,850	N/A	N/A	571 ± 210	30,176 ± 10,628	N/A	N/A	416 ± 202	6,307 ± 5,020	N/A	N/A
	(844–3,233)	(0–30,263)			(198–1,482)	(14,682–82,130)			(0–831)	(0–17,755)