Figure 2.

Motor functions and serum CK level in female mice (WT female mice: N = 5; heterozygotes: N = 5; homozygotes: N = 9). Maximal strength was measured using a grip strength meter with either bar (A) or grid (B), expressed in grams. ^*P < 0.05, ^**P < 0.01. Overall motor capacity was assessed by time on an accelerating rotarod (C), measured in seconds until animals fell. Serum CK level was measured to evaluate muscle damage (D). All data were stratified into four different age groups: 1–2 months (1 and 2 months), 3–5 months (3, 4 and 5 months), 7–10 months (8 and 10 months) and >12 months (12, 16 and 20 months). Data points represent the mean and bars represent SD.