Table 3.
Inhibition constant (Ki) of 3 top-ranked alkaloids with highest affinities for ACE2, TMPRSS2 and SARS-COV-2 spike glycoprotein.
| S/No | Compounds | Inhibition constant (µM) |
||
|---|---|---|---|---|
| ACE2 | TMPRSS2 | SARS-COV-2 S glycoprotein | ||
| R1 | MLN-4760 | 25.62 | ND | ND |
| R2 | N-Acetyl-d-glucosamine | 65.02 | ND | ND |
| R3 | Camostat | ND | 1.56 | ND |
| R4 | Nafamostat | ND | ND | 63.03 |
| 1 | Cryptospirolepine | 2.67 | 6.55 | 23.21 |
| 2 | 10 -Hydroxyusambarensine | 5.81 | 3.20 | ND |
| 3 | Strychnopentamine | 4.45 | ND | ND |
| 4 | Isocryptolepine | ND | ND | 18.11 |
| 5 | Cryptoquindoline | ND | 3.40 | 15.80 |
R1, R2, R3, and R4 are reference inhibitors. ND = not determined.