Table 1.
Pathways enrichment analysis of proteins increased in high glucose cultures
| Pathway name | Count | P value* | Abundance ratio Mean±SD |
Proteins (Uniprot ID) |
| Folding of actin by CCT/TRiC | 5 | 1.37E-06 | 1.61±0.17 | TCPA, TCPB, TCPD, TCPH, TCPZ |
| Cooperation of prefoldin and TRiC/CCT in actin and tubulin folding | 6 | 3.50E-05 | 1.60±0.15 | PFD4, TCPA, TCPB, TCPD, TCPH, TCPZ |
| HSP90 chaperone cycle for steroid hormone receptors | 7 | 8.54E-05 | 1.53±0.08 | CAZA1, CAZA2, DC1I2, DC1L2, DCTN2, DNJA2, HS71A, |
| COPI-independent Golgi-to-ER retrograde traffic | 6 | 4.85E-04 | 1.50±0.10 | CAZA1, CAZA2, DC1I2, DC1L2, DCTN2, RBGPR |
| Golgi-to-ER retrograde transport | 9 | 8.43E-04 | 1.58±0.21 | ARF4, CAZA1, CAZA2, DCL1I2, DCL1L2, DCTN2, GBF1, KINH, RBGPR. |
| Cellular responses to stress | 17 | 2.09E-03 | 1.54±0.13 | CAZA1, CAZA2, DC1I2, DC1L2, DCTN2, DNAJ2, GBF1, HS71A, PRDX2, MK03, NU214, PSDE, PSMD1, PSMD3, SEC13, TERA, TPR |
| Cellular response to heat stress | 7 | 2.02E-03 | 1.57±0.16 | GBF1, HS71A, HS105, MK03, SEC13, TERA, TPR. |
| Glucose metabolism | 7 | 2.43E-03 | 1.49±0.11 | 2AAA, AATC, GNPI2, NU214, PFKAP, SEC13, TPR |
| Intra-Golgi and retrograde Golgi-to-ER traffic | 10 | 4.33E-03 | 1.61±0.24 | ARF4, CAZA1, CAZA2, DC1I2, DC1L2, DCTN2, GBF1, GOGA4, KINH, RBGPR, |
| COPI-mediated anterograde transport | 7 | 3.08E-03 | 1.61±0.23 | ARF4, CAZA1, CAZA2, DC1I2, DC1L2, DCTN2, GBF1 |
*P value is Bonferroni corrected and false discovery rate is <0.05.
CCT, chaperonin containing T-complex protein 1; COPI, coat protein complex I; ER, endoplasmic reticulum; HSP, heat shock protein; TRiC, T-complex protein-1 ring complex.