Title {1}	Early recognition and response to increases in surgical site infections using optimized statistical process control charts—The Early 2RIS Trial: a multicenter cluster randomized controlled trial with stepped wedge design
Trial registration {2a and 2b}.	ClinicalTrials.gov - NCT03075813 All registry items are included in the body of the protocol.
Protocol version {3}	2.1
Funding {4}	United States Federal Government - Agency for Healthcare Quality and Research (AHRQ) R01 HS23821; National Institutes of Health (NIH) 5T32AI100851–02
Author details {5a}	Anderson, Foy, Baker – Duke Center for Antimicrobial Stewardship and Infection Prevention, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC Lokhnygina – Department of Biostatistics and Bioinformatics, Duke University School of Medicine Ilieş, Nehls, Benneyan – Healthcare Systems Engineering Institute, Northeastern University, Boston, MA
Name and contact information for the trial sponsor {5b}	AHRQ
Role of sponsor {5c}	No role outside of financial support