Table 3.
ROC analyses revealing the value of leukocyte and its subtypes in predicting cardiovascular mortality
| Variable | AUC (95% CI) | Cut-off | Sensitivity | Specificity |
|---|---|---|---|---|
| Leukocytes | 0.598 (0.543–0.652) | 8.235 | 0.405 | 0.757 |
| Neutrophils | 0.636 (0.583–0.688) | 4.135 | 0.778 | 0.430 |
| Lymphocytes | 0.373 (0.319–0.427) | 1.385 | 0.559 | 0.660 |
| Monocytes | 0.570 (0.516–0.625) | 0.445 | 0.614 | 0.519 |
| Eosinophils | 0.403 (0.346–0.459) | 0.045 | 0.807 | 0.386 |
| Basophils | 0.355 (0.302–0.408) | 0.015 | 0.726 | 0.480 |
| NMLR | 0.677 (0.626–0.728) | 4.133 | 0.588 | 0.692 |
| NLR | 0.673 (0.622–0.724) | 3.704 | 0.614 | 0.665 |
| MLR | 0.666 (0.614–0.718) | 0.361 | 0.627 | 0.678 |
| ELR | 0.385 (0.330–0.441) | 0.007 | 0.780 | 0.431 |
| Leukocytes model | 0.767 (0.718–0.816) | – | – | – |
| Neutrophils model | 0.775 (0.726–0.823) | – | – | – |
| Lymphocytes model | 0.784 (0.739–0.830) | – | – | – |
| Monocytes model | 0.763 (0.714–0.813) | – | – | – |
| Eosinophils model | 0.771 (0.721–0.820) | – | – | – |
| Basophils model | 0.792 (0.743–0.841) | – | – | – |
| NMLR model | 0.803 (0.759–0.847) | – | – | – |
| NLR model | 0.802 (0.757–0.846) | – | – | – |
| MLR model | 0.788 (0.742–0.834) | – | – | – |
| ELR model | 0.772 (0.722–0.822) | – | – | – |
Other variables in the model: age, male gender, BMI, Family history of CAD, smoking, hypertension, DM, HDL-C, non-HDL-C, hsCRP, Creatinine, LVEF, Troponin I, use of statin, ACE-I/ARB, PCI
AUC area under curve, BMI body mass index, CAD coronary artery disease, DM diabetes mellitus, HDL-C high-density lipoprotein cholesterol, PCI percutaneous coronary intervention, hsCRP high sensitivity C-reactive protein, NMLR neutrophil-plus-monocyte-to-lymphocyte ratio, NLR neutrophil-to-lymphocyte ratio, MLR monocyte-to-lymphocyte ratio, ELR eosinophil-to-leukocyte ratio, ACE-I: agiotensin-converting enzyme inhibitors, ARB angiotensin receptor blockers