Table 2.
Univariable and multivariable analysis of risk
| OS from EOI1 | DFS from EOI1 | RR from EOI1 | TRM from EOI1 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | HR | 95% Cl | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% Cl | P | |
| Univariable | |||||||||||||
| MRD at EOI1 | |||||||||||||
| Negative | 544 | 1 | 1 | 1 | 1 | ||||||||
| Positive | 240 | 2.35 | 1.84-2.98 | <.001 | 2.27 | 1.86-2.78 | <.001 | 2.10 | 1.69-2.60 | <.001 | 1.95 | 1.06-3.58 | .031 |
| Age, y | |||||||||||||
| 2-10 | 276 | 1 | 1 | 1 | 1 | ||||||||
| 0-1 | 156 | 1.09 | 0.77-1.54 | .616 | 1.18 | 0.90-1.56 | .231 | 1.17 | 0.87-1.57 | .292 | 1.19 | 0.34-4.22 | .787 |
| ≥11 | 352 | 1.29 | 0.98-1.69 | .068 | 1.09 | 0.87-1.36 | .456 | 0.88 | 0.70-1.11 | .287 | 4.42 | 1.85-10.5 | .001 |
| WBC, ×103/µL | |||||||||||||
| <100 | 625 | 1 | 1 | 1 | 1 | ||||||||
| ≥100 | 159 | 1.22 | 0.92-1.63 | .163 | 1.58 | 1.26-1.98 | <.001 | 1.78 | 1.40-2.25 | <.001 | 0.41 | 0.15-1.15 | .089 |
| Race | |||||||||||||
| Non–African American | 622 | 1 | 1 | 1 | 1 | ||||||||
| African American | 87 | 1.77 | 1.27-2.45 | .001 | 1.32 | 0.98-1.77 | .067 | 1.16 | 0.85-1.59 | .345 | 1.92 | 0.88-4.19 | .101 |
| Risk group, cyto/mutation | |||||||||||||
| Standard | 404 | 1 | 1 | 1 | 1 | ||||||||
| Low | 273 | 0.32 | 0.23-0.44 | <.001 | 0.41 | 0.32-0.52 | <.001 | 0.37 | 0.29-0.48 | <.001 | 1.13 | 0.56-2.25 | .736 |
| High | 94 | 1.23 | 0.89-1.70 | .205 | 1.22 | 0.92-1.62 | .163 | 1.08 | 0.79-1.49 | .629 | 2.14 | 0.97-4.69 | .059 |
| Induction 1 response by morphology | |||||||||||||
| CR | 576 | 1 | 1 | 1 | 1 | ||||||||
| Not in CR | 200 | 1.60 | 1.23-2.06 | <.001 | 2.38 | 1.93-2.93 | <.001 | 2.35 | 1.86-2.98 | <.001 | 1.12 | 0.56-2.25 | .744 |
| Multivariable | |||||||||||||
| MRD at EOI1 | |||||||||||||
| Negative | 476 | 1 | 1 | 1 | 1 | ||||||||
| Positive | 214 | 1.82 | 1.36-2.44 | <.001 | 1.49 | 1.18-1.90 | .001 | 1.35 | 1.04-1.76 | .023 | 2.20 | 1.01-4.76 | .046 |
| Age, y | |||||||||||||
| 2-10 | 246 | 1 | 1 | 1 | 1 | ||||||||
| 0-1 | 133 | 0.85 | 0.58-1.24 | .400 | 0.89 | 0.65-1.20 | .436 | 0.83 | 0.59-1.17 | .292 | 2.03 | 0.49-8.39 | .327 |
| ≥11 | 311 | 1.44 | 1.08-1.92 | .012 | 1.22 | 0.96-1.54 | .105 | 0.96 | 0.74-1.24 | .766 | 5.67 | 1.98-16.2 | .001 |
| WBC, ×103/µL | |||||||||||||
| <100 | 550 | 1 | 1 | 1 | 1 | ||||||||
| ≥100 | 140 | 1.24 | 0.91-1.68 | .171 | 1.52 | 1.19-1.95 | .001 | 1.74 | 1.32-2.30 | <.001 | 0.46 | 0.16-1.30 | .143 |
| Race | |||||||||||||
| Non–African American | 603 | 1 | 1 | 1 | 1 | ||||||||
| African American | 87 | 1.76 | 1.26-2.47 | .001 | 1.32 | 0.98-1.78 | .067 | 1.19 | 0.87-1.64 | .284 | 1.82 | 0.81-4.09 | .147 |
| Risk group, cyto/mutation | |||||||||||||
| Standard | 367 | 1 | 1 | 1 | 1 | ||||||||
| Low | 240 | 0.31 | 0.21-0.44 | <.001 | 0.42 | 0.32-0.55 | <.001 | 0.39 | 0.29-0.52 | <.001 | 1.09 | 0.50-2.38 | .826 |
| High | 83 | 0.92 | 0.64-1.32 | .646 | 0.96 | 0.70-1.32 | .803 | 0.91 | 0.63-1.33 | .639 | 1.25 | 0.47-3.28 | .657 |
| Induction 1 response by morphology | |||||||||||||
| CR | 516 | 1 | 1 | 1 | 1 | ||||||||
| Not in CR | 174 | 1.11 | 0.82-1.50 | .519 | 2.06 | 1.62-2.63 | <.001 | 2.05 | 1.56-2.68 | <.001 | 0.91 | 0.40-2.07 | .827 |
Bold values in the table body represent statistically significant P values.