Figure 2.

Distribution of mutated genes in CMML and OM-CMML. (A) Frequencies of the 25 genes analyzed by NGS in the CMML and OM-CMML groups. Genes are ordered from the most to the least frequently mutated, combining the CMML and OM-CMML cases. CBL was the only gene mutated at a significantly different frequency in the groups (2.5% vs 20.8%; OM-CMML vs CMML; P = .011). (B) The plot represents all the mutations identified in the TET2 gene classified by the type of alteration, with insertions or deletions of nucleotides (orange) being the most frequent mutations identified. Nonsense mutations, producing a stop codon in the sequence (light blue), and missense mutations, producing a change in 1 amino acid (lime green), were the second most commonly identified. The least common alterations in our cohort were splice site mutations (yellow). No significant differences were observed in the distribution of mutations in TET2 when both disease groups were compared.