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. 2020 Oct 28;17:323. doi: 10.1186/s12974-020-01996-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Depletion of microglia/macrophages attenuates axon damage in the CNS of CLN1 mice. a Immunohistochemical detection of SMI32+ axonal spheroids (arrows) in longitudinal optic nerve sections of 6-month-old Ppt1^+/+, Ppt1^−/− mice and PLX3397-treated Ppt1^−/− mice. Scale bar: 20 μm. b Quantification of SMI32+ axonal spheroids optic nerves showed a significant reduction of ongoing axonal damage after microglia depletion. c Quantification of SMI32+ axonal spheroids of Ppt1^−/− and PLX3397-treated Ppt1^−/− mice separated by their sex did not show any differences regarding axonal spheroids. d Immunohistochemical detection of APP+ axonal spheroids (arrows) in the S1Bf cortex region of 6-month-old Ppt1^+/+, Ppt1^−/−, and PLX3397-treated Ppt1^−/− mice. Scale bar: 20 μm. e Quantification of APP+ axonal spheroids in the S1Bf cortex region revealed that microglia/macrophage depletion did not significantly attenuate ongoing axonal damage within this CNS compartment. f Quantification of APP+ axonal spheroids in the cortex separated by sex showed a non-significant tendency to reduction of spheroid numbers in male but not female PLX3397-treated Ppt1^−/− mice. n = 5 male and 5 female mice per group. One-way ANOVA and Tukey’s post hoc tests. ^#P < 0.05; **^{, ##}P < 0.01; ***P < 0.001. # significant difference to untreated Ppt1^−/− mice of the same sex