Table 3.
Association between clinicopathologic characteristics and HCC patient OS through univariate and multivariate analysis with Cox regression survival model
| Characteristics | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | P-value | HR | 95%CI | P-value | |
| CDK6 (high vs. low) | 0.8 | 0.4–1.4 | 0.400 | 1.0 | 0.5–2.0 | 0.973 |
| RB1 expression (high vs. low) | 0.7 | 0.4–1.3 | 0.230 | 0.7 | 0.3–1.4 | 0.298 |
| Age (>40 vs. ≤ 40) | 2.1 | 0.6–6.8 | 0.224 | 2.7 | 0.7–9.4 | 0.131 |
| Gender (male vs. female) | 0.6 | 0.3–1.1 | 0.082 | 1.0 | 0.5–2.0 | 0.951 |
| Alcohol consumption (yes vs. no) | 0.7 | 0.3–1.6 | 0.381 | 0.6 | 0.2–1.4 | 0.245 |
| Histologic grade (G3–4 vs. G1–2) | 1.3 | 0.8–1.9 | 0.293 | 1.3 | 0.8–1.9 | 0.312 |
| M (M1 vs. M0) | 4.8 | 0.7–35.5 | 0.122 | 2.4 | 0.4–13.9 | 0.323 |
| N (N1 vs. N0) | 3.8 | 0.5–28.0 | 0.188 | 0.1 | 0.0–17.4 | 0.352 |
| T (T3–4 vs. T1–2) | 1.4 | 1.0–2.0 | 0.033 | 0.2 | 0.0–1.9 | 0.160 |
| Clinical stage (III-IV vs. I-II) | 1.5 | 1.1–2.1 | 0.012 | 6.8 | 0.6–74.5 | 0.115 |
| Postoperative ablation embolization (yes vs. no) | 1.1 | 0.4–2.9 | 0.800 | |||
| Radiation therapy (yes vs. no) | 1.2 | 0.2–9.0 | 0.997 | |||
| Family history of cancer (yes vs. no) | 1.5 | 0.8–2.8 | 0.197 | 1.7 | 0.9–3.1 | 0.111 |
| Vascular invasion (yes vs. no) | 1.3 | 0.7–2.5 | 0.384 | 1.2 | 0.6–2.3 | 0.682 |
| E2F2 (high vs. low) | 2.0 | 1.3–3.2 | 0.002 | 2.4 | 1.3–4.2 | 0.004 |
OS Overall survival, T = topography distribution, N = lymph node metastasis; M = distant metastasis, CI Confidence interval