Table 4.
Association between clinicopathologic characteristics and HCC patient DFI through univariate and multivariate analysis with Cox regression survival model
| Characteristics | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | P-value | HR | 95%CI | P-value | |
| CDK6 (high vs. low) | 0.7 | 0.4–1.1 | 0.147 | 0.7 | 0.4–1.3 | 0.310 |
| RB1 expression (high vs. low) | 0.7 | 0.4–1.2 | 0.213 | 1.1 | 0.6–2.1 | 0.656 |
| Age (>40 vs. ≤ 40) | 0.6 | 0.3–1.2 | 0.167 | 0.9 | 0.4–1.9 | 0.748 |
| Gender (male vs. female) | 1.0 | 0.6–1.6 | 0.862 | |||
| Alcohol consumption (yes vs. no) | 1.0 | 0.6–1.9 | 0.915 | |||
| Histologic grade (G3–4 vs. G1–2) | 1.4 | 1.0–1.9 | 0.083 | 1.3 | 0.9–1.8 | 0.228 |
| M (M1 vs. M0) | 5.5 | 0.7–40.4 | 0.722 | |||
| N (N1 vs. N0) | 3.9 | 0.5–28.6 | 0.180 | 1.1 | 0.0–119.9 | 0.953 |
| T (T3–4 vs. T1–2) | 1.6 | 1.2–2.1 | 0.001 | 0.8 | 0.1–5.9 | 0.800 |
| Clinical stage (III-IV vs. I-II) | 1.7 | 1.3–2.3 | 0.000 | 2.5 | 0.3–21.2 | 0.389 |
| Postoperative ablation embolization (yes vs. no) | 3.1 | 1.6–6.0 | 0.001 | 4.3 | 2.0–9.4 | 0.000 |
| Radiation therapy (yes vs. no) | 1.5 | 0.2–10.9 | 0.690 | |||
| Vascular invasion (yes vs. no) | 1.2 | 0.7–2.1 | 0.524 | |||
| Family history of cancer (yes vs. no) | 1.2 | 0.7–2.0 | 0.513 | |||
| E2F2 (high vs. low) | 2.2 | 1.3–3.7 | 0.004 | 2.0 | 1.1–3.7 | 0.029 |
DFI Disease-free interval, T = topography distribution, N = lymph node metastasis, M = distant metastasis, CI Confidence interval