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. 2020 Oct 28;20:1037. doi: 10.1186/s12885-020-07529-2

Table 5.

Association between clinicopathologic characteristics and HCC patient PFI through univariate and multivariate analysis with Cox regression survival model

Characteristics Univariate analysis Multivariate analysis
HR 95%CI P-value HR 95%CI P-value
CDK6 (high vs. low) 0.7 0.4–1.1 0.082 0.7 0.4–1.1 0.119
RB1 expression (high vs. low) 0.8 0.5–1.3 0.374 1.4 0.8–2.5 0.185
Age (>40 vs. ≤ 40) 0.7 0.4–1.3 0.268 1.0 0.5–2.1 0.959
Gender (male vs. female) 0.7 0.5–1.2 0.239 0.9 0.5–1.6 0.747
Alcohol consumption (yes vs. no) 0.9 0.5–1.6 0.804
Histologic grade (G3–4 vs. G1–2) 1.4 1.0–1.9 0.061 1.2 0.9–1.7 0.270
M (M1 vs. M0) 4.9 0.7–36.2 0.118 0.7 0.1–6.8 0.735
N (N1 vs. N0) 3.4 0.5–24.6 0.230 0.8 0.0–89.4 0.925
T (T3–4 vs. T1–2) 1.5 1.2–2.0 0.001 0.7 0.1–5.6 0.748
Clinical stage (III-IV vs. I-II) 1.6 1.2–2.1 0.000 2.2 0.3–18.6 0.458
Postoperative ablation embolization (yes vs. no) 2.8 1.5–5.2 0.001 3.7 1.8–7.9 0.001
Radiation therapy (yes vs. no) 1.3 0.2–9.3 0.806
Family history of cancer (yes vs. no) 1.2 0.7–2.0 0.445 1.1 0.6–1.9 0.732
Vascular invasion (yes vs. no) 1.4 0.8–2.2 0.228 1.2 0.7–2.0 0.579
E2F2 (high vs. low) 1.8 1.2–2.6 0.005 2.2 1.3–3.9 0.005

PFI Progression-free interval, T = topography distribution, N = lymph node metastasis, M = distant metastasis, CI Confidence interval