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. 2020 Oct 28;17:144. doi: 10.1186/s12984-020-00771-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Results of the smoothness metric. Top graphs: Performance for each subject in the four assessment points: T0, pre-treatment assessment of Period 1; T1, post-treatment assessment of Period 1; T2, pre-treatment assessment of Period 2; T3, post-treatment assessment of Period 2. Period 1, from T0 to T1; Wash out, from T1 to T2; Period 2, from T2 to T3. Each subject is indicated by a different symbol and the kind of treatment he/she underwent in each period is marked by the color of the line (yellow for VR and blue for C). Bottom graphs: Performance changes between post- and pre-treatment measurements ( $Δ P$ ) averaged over subjects within each period ( $Δ P 1$ and $Δ P 2$ ). In order to improve the readability of the graphs in such a way to have higher values for better performance, $Δ P$ was multiplied by minus one. Colors distinguish the two groups (experimental sequence). Statistical significances of the $β$ LME model parameters are marked through asterisks (see Eq. 1, $β_{0}$ intercept, $β_{1}$ period, $β_{2}$ treatment, $β_{3}$ baseline, $β_{4}$ period*treatment)