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. 2020 Sep 30;219(11):e202006094. doi: 10.1083/jcb.202006094

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© 2020 Brandt et al.

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Figure 1. — PLK-2 is preferentially targeted to pairing centers in early meiotic prophase despite the presence of SYP-1 T452 phosphorylation in the C. elegans germline. (A) A schematic illustrating the dynamic localization of PLK-2 during meiotic prophase in C. elegans. (B) A schematic and sequence alignment showing the conserved PBD-binding motif within the C-terminal region of SYP-1. C, C-terminus. N, N-terminus. (C) Composite projection images of a whole gonad dissected from wild-type hermaphrodite and stained for DNA and SYP-1 pT452. Scale bar, 50 µm. (D) Immunofluorescence images of leptotene/zygotene nuclei (upper panels) and late pachytene nuclei (lower panels) showing DNA (blue), PLK-2 (red), COSA-1 (white), and SYP-1 pT452 (green). Arrows indicate the localization of PLK-2 to polycomplexes in early meiotic prophase. Scale bar, 5 µm. Diagrams illustrating the results are shown on the right.