Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 30;219(11):e202006094. doi: 10.1083/jcb.202006094

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Brandt et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 8. — Model for targeting PLK-2 to distinct subnuclear structures during meiotic prophase in C. elegans. (A) In the premeiotic region of the germline, CDK-1 primes the localization of PLK-2 to the nuclear envelope. P, phosphorylation. (B) CDK-1 phosphorylates newly expressed SYP-1 at T452 just before the meiotic onset, and a pool of PLK-2 can localize to SC polycomplexes. (C) Upon meiotic entry, CHK-2 becomes active and phosphorylates the pairing center proteins (Kim et al., 2015), which serve as the preferred docking sites for PLK-2. The nucleoplasmic HAL-2/3 complex ensures the PLK-2 localization to pairing centers by promoting CHK-2 activity and by preventing premature association of PLK-2 to SYP proteins. (D) Constrained PLK-2 activity at the pairing centers is essential for proper axis assembly, homologue pairing, and synapsis. (E) CDK-1 is also responsible for targeting PLK-2 to the crossover-designated sites. (F) SYP-1 phosphorylation and PLK-2 are enriched on the SC short arm relative to the crossover site, and this requires PLK-2 kinase activity and a threshold level of crossover within the nucleus. (G) PLK-2 drives the asymmetric SC disassembly. (H) The short arm becomes the site of cohesion loss during meiosis I.